ParkinsonCanadaV1, France, Analysis, bibRecord, 000055

PINK1 deficiency enhances autophagy and mitophagy induction

Identifieur interne : 000055 ( France/Analysis ); précédent : 000054; suivant : 000056

PINK1 deficiency enhances autophagy and mitophagy induction

Auteurs : Rubén G Mez-Sánchez [Espagne] ; Sokhna M S. Yakhine-Diop [Espagne] ; José M. Bravo-San Pedro [Espagne, France] ; Elisa Pizarro-Estrella [Espagne] ; Mario Rodríguez-Arribas [Espagne] ; Vicente Climent [Espagne] ; Francisco E. Martin-Cano [Espagne] ; María E. González-Soltero [Espagne] ; Anurag Tandon [Canada] ; José M. Fuentes [Espagne] ; Rosa A. González-Polo [Espagne]

Source :

Molecular & Cellular Oncology [ 2372-3548 ] ; 2015.

RBID : PMC:4905358

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder with poorly understood etiology. Increasing evidence suggests that age-dependent compromise of the maintenance of mitochondrial function is a key risk factor. Several proteins encoded by PD-related genes are associated with mitochondria including PTEN-induced putative kinase 1 (PINK1), which was first identified as a gene that is upregulated by PTEN. Loss-of-function PINK1 mutations induce mitochondrial dysfunction and, ultimately, neuronal cell death. To mitigate the negative effects of altered cellular functions cells possess a degradation mechanism called autophagy for recycling damaged components; selective elimination of dysfunctional mitochondria by autophagy is termed mitophagy. Our study indicates that autophagy and mitophagy are upregulated in PINK1-deficient cells, and is the first report to demonstrate efficient fluxes by one-step analysis. We propose that autophagy is induced to maintain cellular homeostasis under conditions of non-regulated mitochondrial quality control.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905358

DOI: 10.1080/23723556.2015.1046579
PubMed: 27308585
PubMed Central: 4905358

Affiliations:

Canada, Espagne, France

Links to Exploration step

PMC:4905358

Le document en format XML

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<author><name sortKey="Pizarro Estrella, Elisa" sort="Pizarro Estrella, Elisa" uniqKey="Pizarro Estrella E" first="Elisa" last="Pizarro-Estrella">Elisa Pizarro-Estrella</name>
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<author><name sortKey="Rodriguez Arribas, Mario" sort="Rodriguez Arribas, Mario" uniqKey="Rodriguez Arribas M" first="Mario" last="Rodríguez-Arribas">Mario Rodríguez-Arribas</name>
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</nlm:aff>
<country xml:lang="fr">Espagne</country>
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<author><name sortKey="Martin Cano, Francisco E" sort="Martin Cano, Francisco E" uniqKey="Martin Cano F" first="Francisco E" last="Martin-Cano">Francisco E. Martin-Cano</name>
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</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Gonzalez Soltero, Maria E" sort="Gonzalez Soltero, Maria E" uniqKey="Gonzalez Soltero M" first="María E" last="González-Soltero">María E. González-Soltero</name>
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; Plasencia,<country>Spain</country>
</nlm:aff>
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<author><name sortKey="Tandon, Anurag" sort="Tandon, Anurag" uniqKey="Tandon A" first="Anurag" last="Tandon">Anurag Tandon</name>
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</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<affiliation><nlm:aff id="af0010">These authors contributed equally to this work.</nlm:aff>
</affiliation>
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<author><name sortKey="Gonzalez Polo, Rosa A" sort="Gonzalez Polo, Rosa A" uniqKey="Gonzalez Polo R" first="Rosa A" last="González-Polo">Rosa A. González-Polo</name>
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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<affiliation><nlm:aff id="af0010">These authors contributed equally to this work.</nlm:aff>
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<front><div type="abstract" xml:lang="en"><p>Parkinson's disease (PD) is a neurodegenerative disorder with poorly understood etiology. Increasing evidence suggests that age-dependent compromise of the maintenance of mitochondrial function is a key risk factor. Several proteins encoded by PD-related genes are associated with mitochondria including <italic>PTEN-induced putative kinase 1</italic>
 (<italic>PINK1</italic>
), which was first identified as a gene that is upregulated by PTEN. Loss-of-function <italic>PINK1</italic>
 mutations induce mitochondrial dysfunction and, ultimately, neuronal cell death. To mitigate the negative effects of altered cellular functions cells possess a degradation mechanism called autophagy for recycling damaged components; selective elimination of dysfunctional mitochondria by autophagy is termed mitophagy. Our study indicates that autophagy and mitophagy are upregulated in <italic>PINK1</italic>
-deficient cells, and is the first report to demonstrate efficient fluxes by one-step analysis. We propose that autophagy is induced to maintain cellular homeostasis under conditions of non-regulated mitochondrial quality control.</p>
</div>
</front>
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<tree><country name="Espagne"><noRegion><name sortKey="G Mez Sanchez, Ruben" sort="G Mez Sanchez, Ruben" uniqKey="G Mez Sanchez R" first="Rubén" last="G Mez-Sánchez">Rubén G Mez-Sánchez</name>
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<name sortKey="Bravo San Pedro, Jose M" sort="Bravo San Pedro, Jose M" uniqKey="Bravo San Pedro J" first="José M" last="Bravo-San Pedro">José M. Bravo-San Pedro</name>
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<name sortKey="Fuentes, Jose M" sort="Fuentes, Jose M" uniqKey="Fuentes J" first="José M" last="Fuentes">José M. Fuentes</name>
<name sortKey="Gonzalez Polo, Rosa A" sort="Gonzalez Polo, Rosa A" uniqKey="Gonzalez Polo R" first="Rosa A" last="González-Polo">Rosa A. González-Polo</name>
<name sortKey="Gonzalez Soltero, Maria E" sort="Gonzalez Soltero, Maria E" uniqKey="Gonzalez Soltero M" first="María E" last="González-Soltero">María E. González-Soltero</name>
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<name sortKey="Yakhine Diop, Sokhna M S" sort="Yakhine Diop, Sokhna M S" uniqKey="Yakhine Diop S" first="Sokhna M S" last="Yakhine-Diop">Sokhna M S. Yakhine-Diop</name>
</country>
<country name="France"><noRegion><name sortKey="Bravo San Pedro, Jose M" sort="Bravo San Pedro, Jose M" uniqKey="Bravo San Pedro J" first="José M" last="Bravo-San Pedro">José M. Bravo-San Pedro</name>
</noRegion>
<name sortKey="Bravo San Pedro, Jose M" sort="Bravo San Pedro, Jose M" uniqKey="Bravo San Pedro J" first="José M" last="Bravo-San Pedro">José M. Bravo-San Pedro</name>
<name sortKey="Bravo San Pedro, Jose M" sort="Bravo San Pedro, Jose M" uniqKey="Bravo San Pedro J" first="José M" last="Bravo-San Pedro">José M. Bravo-San Pedro</name>
<name sortKey="Bravo San Pedro, Jose M" sort="Bravo San Pedro, Jose M" uniqKey="Bravo San Pedro J" first="José M" last="Bravo-San Pedro">José M. Bravo-San Pedro</name>
</country>
<country name="Canada"><noRegion><name sortKey="Tandon, Anurag" sort="Tandon, Anurag" uniqKey="Tandon A" first="Anurag" last="Tandon">Anurag Tandon</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/France/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000055 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000055 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     PMC:4905358
   |texte=   PINK1 deficiency enhances autophagy and mitophagy induction
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/France/Analysis/RBID.i   -Sk "pubmed:27308585" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/France/Analysis/biblio.hfd   \
       | NlmPubMed2Wicri -a ParkinsonCanadaV1

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

La maladie de Parkinson au Canada (serveur d'exploration)

PINK1 deficiency enhances autophagy and mitophagy induction

PINK1 deficiency enhances autophagy and mitophagy induction

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.